Home » Chronic inflammation can be affected by muscle exercise

Chronic inflammation can be affected by muscle exercise

Long, thin, well-defined muscle fibers (top left) are in shambles after prolonged inflammation (top right), but maintain their structure (bottom left) and strength (bottom right) when exercised during the inflammation.

Long, thin, well-defined muscle fibers (top left) are in shambles after prolonged inflammation (top right), but maintain their structure (bottom left) and strength (bottom right) when exercised during the inflammation.

 

Exploration Highlights

 

 

  • Biomedical engineers at Duke University have demonstrated that human muscle has an innate ability to ward off the damaging effects of chronic inflammation when exercised.
  • “We discovered that the muscle cells were capable of taking anti-inflammatory actions all on their own.”
  • “We know that chronic inflammatory diseases induce muscle atrophy, but we wanted to see if the same thing would happen to our engineered human muscles grown in a Petri dish,” said Zhaowei Chen.
  • “Not only did we confirm that interferon gamma primarily works through a specific signaling pathway, we showed that exercising muscle cells can directly counter this pro-inflammatory signaling independent of the presence of other cell types or tissues.”
  • They then showed that simulated exercise inhibited a specific molecular pathway in muscle cells, and that two drugs used to treat rheumatoid arthritis, tofacitinib and baricitinib, which block the same pathway, had the same anti-inflammatory effect.
  • “When exercising, the muscle cells themselves were directly opposing the pro-inflammatory signal induced by interferon gamma, which we did not expect to happen,” said Bursac. “These results show just how valuable lab-grown human muscles might be in discovering new mechanisms of disease and potential treatments.

 

 

Original Article: Exercising Muscle Combats Chronic Inflammation On Its Own

More from: Duke University on Innovation2

 

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